Searchable abstracts of presentations at key conferences in endocrinology

ea0037oc2.1 | Reproduction | ECE2015

Decanoic acid inhibits androgen production in vitro and in vivo by regulating HSD3B2: a promising drug candidate for the management of hyperandrogenism in polycystic ovary syndrome

Lee Bao Hui , Tan Huey Min , Li Yu , Zhang Zhiwei , Indran Inthrani Raja , Li Jun , Yong Eu Leong

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism in women, with a high incidence of insulin resistance. Decanoic acid (DA), a naturally occurring 10-carbon fatty acid, has been shown to improve insulin sensitivity and lipid profile in an in vivo model of diabetes without the induction of weight gain. However, the effects of DA on androgen production has not been explored.Aim: The objective o...